{"product_id":"yesnutri-supra-nmn-gold-60s-2-boxes-copy","title":"YesNutri Supra NMN Gold","description":"\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eGolden Formula\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePromote healthy skin and anti-ageing\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSupport body muscle recovery from exercise\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSupport increasing of energy level\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSupport eye health and help to decelerate aging of vision\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePromote general health and wellbeing\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProduct Introduction\u003c\/h3\u003e\n\u003cp\u003eYesNutri Supra NMN Gold contains four star-ingredients: NMN (nicotinamide mononucleotide), astaxanthin, resveratrol, and PQQ, which enhance anti-aging and reverse aging effects, bringing out a healthy and radiant appearance for you.\u003c\/p\u003e\n\u003cp\u003eNMN – Effectively activates cellular functions, slows down aging, and enhances the body's repairability.\u003c\/p\u003e\n\u003cp\u003eAstaxanthin – Helps maintain eye health and delays visual aging.\u003c\/p\u003e\n\u003cp\u003eResveratrol – Highly moisturizing, enhances skin elasticity, and maintains a youthful appearance.\u003c\/p\u003e\n\u003cp\u003ePQQ – Activates brain cells to have more energy, making the brain more agile and clear, and enhancing memory.\u003c\/p\u003e\n\u003ch3\u003eProduct Name\u003c\/h3\u003e\n\u003cp\u003eYesNutri Supra NMN Gold\u003c\/p\u003e\n\u003ch3\u003ePack Size\u003c\/h3\u003e\n\u003cp\u003e30 Veggie Capsule\u003cbr\u003e60 Veggie Capsule\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003ePlace of Origin\u003c\/h3\u003e\n\u003cp\u003eAmerica\u003c\/p\u003e\n\u003ch3\u003eComposition\u003c\/h3\u003e\n\u003cp\u003eEach two capsules contain:\u003c\/p\u003e\n\u003cp\u003eBeta-nicotinamide mononucleotide (NMN) 500mg\u003cbr\u003eResveratrol 50mg\u003cbr\u003ePyrroloquinoline Quinone (PQQ) 50mg\u003cbr\u003eAstaxanthin 4mg\u003cbr\u003eBeta-carotene 64mcg\u003cbr\u003eLutein 60mcg\u003c\/p\u003e\n\u003ch3\u003eDirection\u003c\/h3\u003e\n\u003cp\u003eAdults take 1-2 capsules daily with meal or as recommended by your physicians.\u003c\/p\u003e\n\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eYesNutri SUPRA NMN Gold contains highly concentrated NMN (Nicotinamide mononucleotide), a biosynthetic precursor of NAD+, which is known to promote the production of NAD+ in cells and counteract the aging-associated diseases associated with the decline in tissue NAD+ levels.\u003csup\u003e14\u003c\/sup\u003e Scientific research shows that NMN (Nicotinamide mononucleotide) can effectively activate cell functions, delay aging, and strengthen the body's ability to repair.\u003csup\u003e12,13,16\u003c\/sup\u003e Nicotinamide adenine dinucleotide (NAD+) is a central signaling molecule involved in cellular processes related to age-related diseases, indicating that NAD+ decline is the main feature of accelerated aging. Certain studies have shown that the NAD+ production mechanism along the age becomes worse and the NAD+ level becomes lower. It has been found that a special transporter (Slc12a8) directly enters the cell to produce NAD+ in the body to maintain the NAD+ level, thereby slowing down the premature aging syndrome and normal aging.\u003csup\u003e14-16\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eAstaxanthin of Yesnutri Supra NMN Gold is extracted from natural Haematococcus pluvialis. The astaxanthin content of Haematococcus pluvialis is more than 10 times that of krill oil.\u003csup\u003e3-6\u003c\/sup\u003e It is scientifically proven that astaxanthin has potent antioxidant and hepatoprotective effect and has high nutritional value.\u003csup\u003e1-2,9,11\u003c\/sup\u003e Astaxanthin has a unique molecular structure, which allows it to have extraordinary chemical properties. It has no less than ten times or higher than other carotenoids such as lutein and β-carotene.\u003csup\u003e1,7,8,10\u003c\/sup\u003e Meanwhile, it can prevent cell membrane oxidation and stop the chain reaction of free radicals.\u003csup\u003e1,7,10,16\u003c\/sup\u003e Astaxanthin can cross the blood-brain barrier and enter the retinal tissue to provide protection for the retina, reduce damage caused by ultraviolet rays, and accelerate recovery, which is very helpful to relieve eye discomfort.\u003c\/p\u003e\n\u003cp\u003eResveratrol is a strong natural antioxidant. Resveratrol can activate expression of the longevity gene SIRT1 to slow down aging and help maintain proper cell metabolism.\u003csup\u003e19\u003c\/sup\u003e It can suppress melanin formation beneath skin and reduce dark spots.\u003csup\u003e20\u003c\/sup\u003e Moreover, resveratrol can help the skin resist water loss and pump water back to the cells. It contributes to an overall skin whitening and moisturizing effect.\u003csup\u003e21\u003c\/sup\u003e Anti-oxidizing property of resveratrol allows heart, blood vessels, pancreas, and kidney to stay healthy. Resveratrol can improve energy release from glucose to support daily energy needs.\u003c\/p\u003e\n\u003cp\u003ePQQ is a multifunctional nutrient found in plant-based foods, commonly found in leafy vegetables, fruits, and legumes. It provides extensive benefits for the brain and body, including stimulating mitochondrial biogenesis\u003csup\u003e17\u003c\/sup\u003e, producing nerve growth factor (NGF)\u003csup\u003e18\u003c\/sup\u003e, providing powerful antioxidant activity, reducing inflammation, and extending the lifespan of organs rich in mitochondria such as the heart, brain, liver, and others. Mitochondria produces the vast majority of cellular energy (ATP), playing an important role in our overall health. PQQ stimulates mitochondrial growth and replication\u003csup\u003e17\u003c\/sup\u003e. More mitochondria will produce more cellular energy (ATP) production, and the more energy in cells, the better each organ in the body will function. For example, enhancing brain cell energy will make the brain clearer, and enhancing skin cell energy will make wounds heal faster. Nerve growth factor (NGF) is a protein that plays a crucial role in the growth, development, and maintenance of neurons. Studies have shown that PQQ can promote the production of NGF\u003csup\u003e18\u003c\/sup\u003e. Increasing NGF levels helps maintain the health of the brain and peripheral nerves and stimulates brain cell regeneration.\u003c\/p\u003e\n\u003ch4\u003eBenefit of Lutein\u003c\/h4\u003e\n\u003cp\u003eLutein is a natural carotenoid which can be found in the macula and the rest of the retina. Lutein could not be synthesized in mammals and must be obtained from the diet. It is a yellowish pigment which could filter blue light at the high energy end of the visible spectrum, thus reducing UV radiation toxicity to the retina and the skin. At the same time, lutein has antioxidant ability which can protect eyes and skin by reducing oxidative damage to cells.\u003c\/p\u003e\n\u003cp\u003eThe above nutrients are beneficial for slowing down aging, protecting the eyes, skincare, promoting brain health, and improving heart and cardiovascular health. They are suitable for people who are concerned about these aspects of health.\u003c\/p\u003e\n\u003ch4\u003e參考文獻：\u003c\/h4\u003e\n\u003ch4\u003eReferences\u003c\/h4\u003e\n\u003col\u003e\n\u003cli\u003eAmbati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications–A Review. Mar Drugs. 2014;12(1):128-52. doi: 10.3390\/md12010128.\u003c\/li\u003e\n\u003cli\u003eKistler A, Liechti H, Pichard L, Wolz E, Oesterhelt G et al. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch Toxicol. 2002;75(11-12):665-75.\u003c\/li\u003e\n\u003cli\u003eLorenz RT, Cysewski GR. Commercial potential for Haematococcous microalgae as a natural source of Astaxanthin. Trends Biotechnol. 2000;18(4):160-7.\u003c\/li\u003e\n\u003cli\u003eKwantes JM, Grundmann O. A brief review of krill oil history, research, and the commercial market. J. Diet Suppl. 2004 Apr 1.\u003c\/li\u003e\n\u003cli\u003eKrill – Marine Lipid Complex Technical Data Sheet. NutriScience Innovations: Product Information. Available online at http:\/\/www.nutriscienceusa.com\/KrillOilMLC.htm\u003c\/li\u003e\n\u003cli\u003eFish oil vs. krill oil. Omega-Research. Available online at http:\/\/www.omega-research.com\/\u003c\/li\u003e\n\u003cli\u003eYuan JP, Peng J, Yin K, Wang JH. Potential health-promoting effects of Astaxanthin: A high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011;55(1):150-65.\u003c\/li\u003e\n\u003cli\u003eSpiller GA, Dewell A. Safety of an Astaxanthin-Rich Haematococcus pluvialis Algal Extract: A Randomized Clinical Trial. J Med Food. 2003 Spring;6(1):51-6.\u003c\/li\u003e\n\u003cli\u003eAstaxanthin. Martindale: The Complete Drug Reference. Available online at: http:\/\/www.medicinescomplete.com\u003c\/li\u003e\n\u003cli\u003eKidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011;16(4):355-64.\u003c\/li\u003e\n\u003cli\u003eFassett RG, Coombes JS. Astaxanthin: A potential therapeutic agent in cardiovascular disease. Mar Drugs. 2011;9(3):447-65.\u003c\/li\u003e\n\u003cli\u003eYoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528. doi: 10.1016\/j.cmet.2017.11.002. Epub 2017 Dec 14. PMID: 29249689; PMCID: PMC5842119.\u003c\/li\u003e\n\u003cli\u003eKiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Geroscience. 2019 Oct;41(5):619-630. doi: 10.1007\/s11357-019-00074-2. Epub 2019 May 29. PMID: 31144244; PMCID: PMC6885080.\u003c\/li\u003e\n\u003cli\u003eGrozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57. doi: 10.1038\/s42255-018-0009-4. Epub 2019 Jan 7. Erratum in: Nat Metab. 2019 Jul;1(7):743. PMID: 31131364; PMCID: PMC6530925.\u003c\/li\u003e\n\u003cli\u003eKincaid JW, Berger NA. NAD metabolism in aging and cancer. Experimental Biology and Medicine. 2020;245(17):1594-1614. doi:10.1177\/1535370220929287\u003c\/li\u003e\n\u003cli\u003eKane, A. and D. Sinclair. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research .2018(123): 868–885.\u003c\/li\u003e\n\u003cli\u003ePyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression. 2009 Oct 27; PMCID: PMC2804159\u003c\/li\u003e\n\u003cli\u003eStimulation of Nerve Growth Factor Production by Pyrroloquinoline Quinone and Its Derivatives in Vitro and in Vivo, Bioscience, Biotechnology, and Biochemistry, 57:7, 1231-1233, DOI: 10.1271\/bbb.57.1231\u003c\/li\u003e\n\u003cli\u003eSarubbo F, Esteban S, Miralles A, Moranta D. Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging. Curr Neuropharmacol. 2018 Jan 30;16(2):126-136. doi: 10.2174\/1570159X15666170703113212. PMID: 28676015; PMCID: PMC5883375.\u003c\/li\u003e\n\u003cli\u003eBoo YC. Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications. Antioxidants (Basel). 2019 Aug 22;8(9):332. doi: 10.3390\/antiox8090332. PMID: 31443469; PMCID: PMC6770230.\u003c\/li\u003e\n\u003cli\u003eXia N, Daiber A, Förstermann U, Li H. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 2017 Jun;174(12):1633-1646. doi: 10.1111\/bph.13492. Epub 2016 May 6. PMID: 27058985; PMCID: PMC5446570.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"YesNutri \/ Herb and Nutrition","offers":[{"title":"30 Tablets \/ No outer boxes","offer_id":47861680799895,"sku":null,"price":980.0,"currency_code":"HKD","in_stock":true},{"title":"30 Tablets \/ Require outer box (it will be provided if available)","offer_id":47861680832663,"sku":null,"price":980.0,"currency_code":"HKD","in_stock":true},{"title":"60 Tablets \/ No outer boxes","offer_id":47861680865431,"sku":null,"price":1580.0,"currency_code":"HKD","in_stock":true},{"title":"60 Tablets \/ Require outer box (it will be provided if available)","offer_id":47861680898199,"sku":null,"price":1580.0,"currency_code":"HKD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0721\/2980\/6487\/files\/SUPRA_NMN_GOLD_Chin_main.jpg?v=1781755314","url":"https:\/\/yesnutri.com\/en\/products\/yesnutri-supra-nmn-gold-60s-2-boxes-copy","provider":"YesNutri","version":"1.0","type":"link"}