What is Glucosamine & Chondroitin?
Glucosamine is an amino sugar which exists in our body in form of proteoglycans. Proteoglycan is found in articular cartilage and other connective tissues. Proteoglycans viscoelastic property keeps large amount of water in cartilage, reduce friction and absorb shock.
Glucosamine is important for maintaining the elasticity, strength and resiliency of the cartilage in joints. Clinically proven, administration of glucosamine stimulates mucopolysaccharide and collagen synthesis in cartilage tissue and allows rebuilding of damaged cartilage. In addition to supporting cartilage, glucosamine enhances both the production of hyaluronic acid and its anti-inflammatory action.
Chondroitin is one of the natural glycosaminglycans that is synthesized endogenously and secreted by the chondrocytes, constituents most of the cartilaginous tissues. Chondroitin absorbs water, adds thickness and elasticity of cartilage and enhances its ability to absorb compressive forces. It also controls the formation of new cartilage matrix, by stimulating chondrocyte metabolism and synthesis of collagen and proteoglycan. Chondroitin reduces cartilage destruction and maintains joint function by inhibiting degradative enzymes which break down cartilage matrix and synovial fluid.
Why do we need Glucosamine & Chondroitin?
Cartilage is mainly composed of water, which its level decreases with age. About 85% of cartilage is water in young people, while it drops to about 70% water in older people. With decrease of water content, the cartilage become harder. This explains why joint movements usually become less smooth as we age.
Osteoarthritis is the clinical and pathological outcome of a range of disorders that cause structural and functional failure of synovial joints; result in wearing of the ends of the bones in a joint. It is characterised by involvement of the entire joint, with loss and erosion of articular cartilage, mild to moderate synovial inflammation, and outgrowth of bone and cartilage at the joint margins (osteophytes). These changes result in pain, stiffness (especially after inactivity) and reduced mobility, although patients with these changes characteristic of osteoarthritis are often asymptomatic. Mechanical factors such as misalignment and muscle weakness contribute to joint damage and loss of function. The joints most often affected are hands, hips, and knees.
Conventional anti-inflammatory drugs and pain-killer very often irritate the stomach, leading to gastrointestinal discomfort and lack of appetite. In contrast, glucosamine and chondroitin is natural and neutral and would not cause disturbances to the stomach. They are the optimal supplement for joint health.