卓營方 Supra NMN 30000+

YesNutri Supra NMN 30000+ contains five upgraded ingredients – NMN, coenzyme Q10, PQQ, resveratrol, and astaxanthin. Each capsule contains 500 mg of NMN with a purity of 99.9%. Combined with the other four highly effective antioxidant components, it helps you maintain youthfulness, keep unlimited vitality, and achieve the optimal anti-aging effect.

NMN – Activates cellular functions, slows down aging, and enhances the body’s repairability.

Astaxanthin –Maintains eye health and delays visual aging.

Resveratrol – Highly moisturizing, enhances skin elasticity, and maintains a youthful appearance.

PQQ – Activates brain cells to have more energy, making the brain more agile and clear, and enhancing memory.
Coenzyme Q10 – Promotes cellular energy conversion and metabolism, strengthen heart function

YesNutri Supra NMN 30000+

60 Veggie Capsules

America

First using: take 1 capsule dailt in the first month continuously.

Adcanced care: take 1-2 capsules daily or as directed by physicians.

Store below 25 degrees in a dry and cool place.

Keep out of reach of children.

YesNutri SUPRA NMN 30000+ contains a high content and purity of NMN (Nicotinamide mononucleotide), a biosynthetic precursor of NAD+, which is known to promote the production of NAD+ in cells and counteract the aging-associated diseases associated with the decline in tissue NAD+ levels. ^[14] Scientific research shows that NMN can effectively activate cell functions, delay aging, and strengthen the body’s ability to repair. ^[12,13,16] Nicotinamide adenine dinucleotide (NAD+) is a central signaling molecule involved in cellular processes related to age-related diseases, indicating that NAD+ decline is the main feature of accelerated aging. Certain studies have shown that the NAD+ production mechanism along the age becomes worse and the NAD+ level becomes lower. It has been found that a special transporter (Slc12a8) directly enters the cell to produce NAD+ in the body to maintain the NAD+ level, thereby slowing down the premature aging syndrome and normal aging. ^[14-16]

Astaxanthin is extracted from natural Haematococcus pluvialis. Canthaxanthin, beta carotene and lutein naturally exist in Haematococcus pluvialis. The astaxanthin content of Haematococcus pluvialis is more than 10 times that of krill oil. ^[3-6] It is scientifically proven that astaxanthin has potent antioxidant and hepatoprotective effect and has high nutritional value. ^[1-2,9,11] Astaxanthin has a unique molecular structure, which allows it to have extraordinary chemical properties. It has no less than ten times or higher than other carotenoids such as lutein and β-carotene. ^[1,7,8,10] Meanwhile, it can prevent cell membrane oxidation and stop the chain reaction of free radicals. ^[1,7,10,16] Astaxanthin can cross the blood-brain barrier and enter the retinal tissue to provide protection for the retina, reduce damage caused by ultraviolet rays, and accelerate recovery, which is very helpful to relieve eye discomfort.

Lutein is a natural carotenoid which can be found in the macula and the rest of the retina. Lutein could not be synthesized in mammals and must be obtained from the diet.  It is a yellowish pigment which could filter blue light at the high energy end of the visible spectrum, thus reducing UV radiation toxicity to the retina and the skin. At the same time, lutein has antioxidant ability which can protect eyes and skin by reducing oxidative damage to cells.  ^[22]

Resveratrol is a strong natural antioxidant. Resveratrol can activate expression of the longevity gene SIRT1 to slow down aging and help maintain proper cell metabolism ^[19]. It can suppress melanin formation beneath skin and reduce dark spots ^[20]. Moreover, resveratrol can help the skin resist water loss and pump water back to the cells. It contributes to an overall skin whitening and moisturizing effect. ^[21] Anti-oxidizing property of resveratrol allows heart, blood vessels, pancreas, and kidney to stay healthy. Resveratrol can improve energy release from glucose to support daily energy needs.

PQQ is a multifunctional nutrient found in plant-based foods, commonly found in leafy vegetables, fruits, and legumes. It provides extensive benefits for the brain and body, including stimulating mitochondrial biogenesis ^[17], producing nerve growth factor (NGF) ^[18], providing powerful antioxidant activity, reducing inflammation, and extending the lifespan of organs rich in mitochondria such as the heart, brain, liver, and others.  Mitochondria produces the vast majority of cellular energy (ATP), playing an important role in our overall health. PQQ stimulates mitochondrial growth and replication ^[17]. The more energy produced in cells, the better each organ in the body will function. For example, enhancing brain cell energy will make the brain clearer, and enhancing skin cell energy will make wounds heal faster.

Nerve growth factor (NGF) is a protein that plays a crucial role in the growth, development, and maintenance of neurons. Studies have shown that PQQ can promote the production of NGF ^[18]. Increasing NGF levels helps maintain the health of the brain and peripheral nerves and stimulates brain cell regeneration.

Coenzyme Q10 is an important antioxidant that protects cells and bodily structures. It can eliminate harmful free radicals within cells, slowing cellular aging. Coenzyme Q10 is widely distributed in the body, with high-energy tissues like the heart, kidneys, liver, and muscles having greater demand for it. ^[23] It participates in cellular energy production, assisting metabolism and increasing energy supply to maintain normal bodily functions. Coenzyme Q10 can strengthen the heart, delay vascular aging, and protect cardiovascular health.^[24] It can also enhance muscle endurance, improve physical performance, and maintain mental vitality.^[25]

The above nutrients are beneficial for slowing down aging, protecting the eyes, skincare, promoting brain health, and improving heart and cardiovascular health. This product is suitable for people who are concerned about these aspects of health.

References:

1. Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications–A Review. Mar Drugs. 2014;12(1):128-52. doi: 10.3390/md12010128.
2.  Kistler A, Liechti H, Pichard L, Wolz E, Oesterhelt G et al. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch Toxicol. 2002;75(11-12):665-75.
3.  Lorenz RT, Cysewski GR. Commercial potential for Haematococcous microalgae as a natural source of Astaxanthin. Trends Biotechnol. 2000;18(4):160-7.
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14. Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57. doi: 10.1038/s42255-018-0009-4. Epub 2019 Jan 7. Erratum in: Nat Metab. 2019 Jul;1(7):743. PMID: 31131364; PMCID: PMC6530925.
15. Kincaid JW, Berger NA. NAD metabolism in aging and cancer. Experimental Biology and Medicine. 2020;245(17):1594-1614. doi:10.1177/1535370220929287
16. Kane, A. and D. Sinclair. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research .2018(123): 868–885.
17. Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression. 2009 Oct 27; PMCID: PMC2804159
18. Stimulation of Nerve Growth Factor Production by Pyrroloquinoline Quinone and Its Derivatives in Vitro and in Vivo, Bioscience, Biotechnology, and Biochemistry, 57:7, 1231-1233, DOI: 10.1271/bbb.57.1231
19. Sarubbo F, Esteban S, Miralles A, Moranta D. Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging. Curr Neuropharmacol. 2018 Jan 30;16(2):126-136. doi: 10.2174/1570159X15666170703113212. PMID: 28676015; PMCID: PMC5883375.
20. Boo YC. Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications. Antioxidants (Basel). 2019 Aug 22;8(9):332. doi: 10.3390/antiox8090332. PMID: 31443469; PMCID: PMC6770230.
21. Xia N, Daiber A, Förstermann U, Li H. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 2017 Jun;174(12):1633-1646. doi: 10.1111/bph.13492. Epub 2016 May 6. PMID: 27058985; PMCID: PMC5446570.
22. Chae, S. Y., Shin, M. C., Jeon, S., Kang, M. S., Han, D.-W., & Hong, S. W. (2021). A simple route to the complexation of lutein with reduced graphene oxide nanocarriers and antioxidant protection against Blue Light. International Journal of Nanomedicine, Volume 16, 6843–6860. https://doi.org/10.2147/ijn.s320790

23. Bhagavan, H. N., & Chopra, R. K. (2006). Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radical Research, 40(5), 445–453. https://doi.org/10.1080/10715760600617843
24. Fedacko, J. (2011). Coenzyme Q10 in heart and brain diseases. The Open Nutraceuticals Journal, 4(1), 69–87. https://doi.org/10.2174/1876396001104010069
25. Siebrecht, S., Chan, D. Y. L., Rosenfeld, F., & Lin, K. W. (2015). Coenzyme Q10 and ubiquinol for physical performance. Coenzyme Q10: From Fact to Fiction; Hargreaves, I., Ed.