YesNutri SUPRA NMN

YesNutri SUPRA NMN

YesNutri SUPRA NMN contains star ingredients, NMN (nicotinamide mononucleotide) and natural Haematococcus pluvialis extract. It is suitable for people who are concerned about anti-aging, physical fitness, skin, eyes, liver, brain, heart and cardiovascular health.

Astaxanthin of  Yesnutri Supra NMN is extracted from natural Haematococcus pluvialis. The astaxanthin content of Haematococcus pluvialis is more than 10 times that of krill oil. ^[3-6] It is scientifically proven that astaxanthin has potent antioxidant and hepatoprotective effect, and has high nutritional value. ^[1,9,22] Astaxanthin has a unique molecular structure, which allows it to have extraordinary chemical properties. It has no less than ten times or higher than other carotenoids such as lutein and β-carotene. [1,7,8,10] Meanwhile, it can prevent cell membrane oxidation and stop the chain reaction of free radicals. [1,7,10,16] Astaxanthin can cross the blood-brain barrier and enter the retinal tissue to provide protection for the retina, reduce damage caused by ultraviolet rays, and accelerate recovery, which is very helpful to relieve eye discomfort. ^[17-19] Adequate intake of antioxidants is important for the health of men, women, and children. It can improve overall health in old age and effectively maintain good cognitive ability and longevity. ^[14]

YesNutri SUPRA NMN added NMN (Nicotinamide mononucleotide) is a biosynthetic precursor of NAD+, which is known to promote the production of NAD+ in cells and counteract the aging-associated diseases associated with the decline in tissue NAD+ levels. ^[30] Scientific research shows that NMN (Nicotinamide mononucleotide) can effectively activate cell functions, delay aging, and strengthen the body’s ability to repair. ^[28,29,32] Nicotinamide adenine dinucleotide (NAD+) is a central signaling molecule involved in cellular processes related to age-related diseases, indicating that NAD+ decline is the main feature of accelerated aging. Certain studies have shown that the NAD+ production mechanism along the age becomes worse and the NAD+ level becomes lower. It has been found that a special transporter (Slc12a8) directly enters the cell to produce NAD+ in the body to maintain the NAD+ level, thereby slowing down the premature aging syndrome and normal aging. ^[30-32]

NMN (nicotinamide mononucleotide) benefits for organs

Sirtuins genes are involved in the process of aging and apoptosis. Studies have shown that NMN (nicotinamide mononucleotide) activates the Sirtuins gene to produce Sirtuins for stimulating cell repair, especially for tissues that do not regrow, such as the heart, eyes and brain, slowing down the process of cell death, and subsequent aging. It is expected that disease can be suppressed and restored while promoting cell repair mechanisms. ^[32,34]

Benefits for eyes

YesNutri SUPRA NMN is rich supply of NMN (nicotinamide mononucleotide), natural carotenoids such as astaxanthin, lutein, beta-carotene and canthaxanthin. They cannot be synthesized by the human body and they must be intake from food or dietary supplements. ^[1-2] Lutein is a natural carotenoid, which is a component of macular spots (Yellow spot) and other parts of the retina. ^[11] The blue light is the spectrum that can cause damage the eyes and skin. Lutein can filter the blue light, thereby reducing the damage of ultraviolet rays to the eyes and skin. ^[11-13]

NMN can maintain the immune system, healthy eye tissues and good vision. Studies have shown that a rapid decline in NAD + levels can cause rapid neurodegeneration and vision loss in the eyes. However, scientists have found that supplementing this molecule can prevent adverse reactions and improve vision. ^[15,33-35] Some studies have even shown that NMN will produce deacetylase-cytoprotective enzymes (SIRT1-7) after activating the Sirtuins genes, which have anti-aging effect and slowing down cell apoptosis. NMN increases the cytoprotective enzyme SIRT1 level, which can reduce oxidative stress in retinal cells and inflammation, and then lower risk in damage to the retina. ^[35]

Functions of YesNutri SUPRA NMN Capsules:

• Strong antioxidant ^[1,9,17,28]
• Enhance immune system ^[1,17]
• Provide protection for our cell against UV and free radical damage ^{[1,7,13-17,20,31]}
• Promote general health and wellbeing ^[1,17,28]
• Promote healthy skin and anti-ageing ^{[7,17,20-21,28,31]}
• Promote healthy cardiovascular system ^{[1,7,17,23-24,29,32]}
• Promote healthy liver ^[2,7,17,32]
• Support increasing of energy level ^[24-25,28]
• Support body muscle recovery from exercise ^[7,26]
• Support eye health and help to decelerate aging of vision ^{[7,15-18,27,32-35]}

Recommended daily dose:

Adults take 2 capsules daily with meal or as recommended by your physicians.

Precautions: If you are pregnant or breastfeeding, consult your physician prior to using this product.

References:

1. Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications–A Review. Mar Drugs. 2014;12(1):128-52. doi: 10.3390/md12010128.
2. Kistler A, Liechti H, Pichard L, Wolz E, Oesterhelt G et al. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch Toxicol. 2002;75(11-12):665-75.
3. Lorenz RT, Cysewski GR. Commercial potential for Haematococcous microalgae as a natural source of Astaxanthin. Trends Biotechnol. 2000;18(4):160-7.
4. Kwantes JM, Grundmann O. A brief review of krill oil history, research, and the commercial market. J. Diet Suppl. 2004 Apr 1.
5. Krill – Marine Lipid Complex Technical Data Sheet. NutriScience Innovations: Product Information. Available online at http://www.nutriscienceusa.com/KrillOilMLC.htm
6. Fish oil vs. krill oil. Omega-Research. Available online at http://www.omega-research.com/
7. Yuan JP, Peng J, Yin K, Wang JH. Potential health-promoting effects of Astaxanthin: A high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011;55(1):150-65.
8. Spiller GA, Dewell A. Safety of an Astaxanthin-Rich Haematococcus pluvialis Algal Extract: A Randomized Clinical Trial. J Med Food. 2003 Spring;6(1):51-6.
9. Martindale: The Complete Drug Reference. Available online at: http://www.medicinescomplete.com
10. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011;16(4):355-64.
11. Kijlstra A, Tian Y, Kelly ER, Berendschot TT. Lutein: More than just a filter for blue light. Prog Retin Eye Res. 2012;31(4):303-15.
12. Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K. Neuroprotective effects of lutein in the retina. Curr Pharm Des. 2012; 18(1):51-6.
13. Carpenter KL, van der Veen C, Hird R, Dennis IF, Ding T, Mitchinson MJ. The carotenoids beta-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDLoxidation. FEBS Lett. 1997;401(2-3):262-6.
14. Barros MP, Poppe SC, Bondan EF. Neuroprotective properties of the marine carotenoid astaxanthin and omega-3 Fatty acids, and perspectives for the natural combination of both in krill oil. Nutrients. 2014;6(3):1293-317.
15. Lin JB, Kubota S, Ban N, Yoshida M, Santeford A, Sene A, Nakamura R, Zapata N, Kubota M, Tsubota K, Yoshino J, Imai SI, Apte RS. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016 Sep 27;17(1):69-85. doi: 10.1016/j.celrep.2016.08.073. PMID: 27681422; PMCID: PMC5104206.
16. Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K et al. Amelioration of ultraviolet-induced photokeratitis in mice treated with Astaxanthin eye drops. Mol Vis. 2012;18:455-64.
17. Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol. 2003;21(5):210-6.
18. Ohgami K, Shiratori K, Kotake S, Nishida T, Mizuki N et al. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol Vis Sci. 2003;44(6):2694-701.
19. Suzuki Y, Ohgami K, Shiratori K, Jin XH, Ilieva I et al. Suppressive effects of astaxanthin against rat endotoxin induced uveitis by inhibiting the NF-kB signaling pathway. Exp Eye Res. 2006;82(2):275-81.
20. Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R et al. Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage. J Pharm Sci. 2012;101(8):2909-16.
21. Santos SD, Cahú TB, Firmino GO, de Castro CC, Carvalho LB Jr et al. Shrimp waste extract and astaxanthin: Rat alveolar macrophage, oxidative stress and inflammation. J Food Sci. 2012;77(7):H141-6.
22. Fassett RG, Coombes JS. Astaxanthin: A potential therapeutic agent in cardiovascular disease. Mar Drugs. 2011;9(3):447-65.
23. Fassett RG, Coombes JS. Astaxanthin in cardiovascular health and disease. Molecules. 2012;17(2):2030-48.
24. Song XD, Zhang JJ, Wang MR, Liu WB, Gu XB, Lv CJ. Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells. Biol Pharm Bull. 2011;34(6):839-44.
25. Wolf AM, Asoh S, Hiranuma H, Ohsawa I, Iio K et al. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem. 2010;21(5):381-9.
26. Djordjevic B, Baralic I, Kotur-Stevuljevic J, Stefanovic A, Ivanisevic J et al. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young players. J Sports Med Phys Fitness. 2012;52(4):382-92.
27. Cort A, Ozturk N, Akpinar D, Unal M, Yucel G et al. Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure. Regul Toxicol Pharmacol. 2010;58(1):121-30.
28. Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528. doi: 10.1016/j.cmet.2017.11.002. Epub 2017 Dec 14. PMID: 29249689; PMCID: PMC5842119.
29. Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Geroscience. 2019 Oct;41(5):619-630. doi: 10.1007/s11357-019-00074-2. Epub 2019 May 29. PMID: 31144244; PMCID: PMC6885080.
30. Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57. doi: 10.1038/s42255-018-0009-4. Epub 2019 Jan 7. Erratum in: Nat Metab. 2019 Jul;1(7):743. PMID: 31131364; PMCID: PMC6530925.
31. Kincaid JW, Berger NA. NAD metabolism in aging and cancer. Experimental Biology and Medicine. 2020;245(17):1594-1614. doi:1177/1535370220929287
32. Kane, A. and D. Sinclair. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research .2018(123): 868–885.
33. Ebeling, Mara & Polanco, Jorge & Qu, Jun & Tu, Chengjian & Montezuma, Sandra & Ferrington, Deborah. (2020). Improving retinal mitochondrial function as a treatment for age-related macular degeneration. Redox Biology. 34. 101552. 10.1016/j.redox.2020.101552.
34. Jadeja RN, Thounaojam MC, Bartoli M, Martin PM. Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration. Oxid Med Cell Longev. 2020 May 9;2020:2692794. doi: 10.1155/2020/2692794. PMID: 32454935; PMCID: PMC7238357.
35. Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020 Dec 29;12. doi: 10.18632/aging.202453. Epub ahead of print. PMID: 33373320.

Disclaimer:
(1)This product is not registered under the Pharmacy and Poisons Ordinance or the Chinese
Medicine Ordinance. Any claim made for it has not been subject to evaluation for such registration. This product is not intended to diagnose, treat or prevent any disease.
(2)This product contains natural ingredients, and color differences depends on seasonal purchases. It may appear from light red to orange-red color, which is a normal phenomenon. Products are produced according to cGMP standards, quality assurance, and safe consumption. If you have any questions, please contact us.