产品简介:
卓营方Supra NMN配方蕴含NMN(烟酰胺单核苷酸)及天然的雨生红球藻精华两大星级成分,适合关注推迟衰老、体能、皮肤、眼睛、肝脏、脑部、心脏及心血管健康的人士服用。
卓营方Supra NMN的虾青素是萃取自天然的雨生红球藻。雨生红球藻的虾青素含量是磷虾油10倍以上。[3-6]科学证明虾青素有强效抗氧化和护肝功能,营养价值很高。[1,9,22] 虾青素具有独特的分子结构,让它能有非凡效益的化学特质,有着比其他类胡萝卜素如叶黄素、β-胡萝卜素等不少于十倍或更高的抗氧化功效。[1,7,8,10] 同时能阻止细胞膜氧化,终止自由基连锁反应。[1,7,10,16] 虾青素能穿越血脑屏障进入视网膜组织,为视网膜提供防护,减低紫外线造成的伤害,同时加速复原,为纾缓眼部不适非常有帮助。[17-19]摄取足够的抗氧化剂对男女老少的健康均为重要,能提升老年时整体健康,并有效保持良好认知能力及长寿。[14]
卓营方Supra NMN更添加烟酰胺单核苷酸(NMN)是NAD+的生物合成前体,已知可促进细胞NAD+的产生并抵消与组织NAD +水平下降有关的与年龄相关的病理。[30]
科研实证NMN(烟酰胺单核苷酸),有效地活化细胞机能,推迟衰老,亦能加强身体修复能力。[28,29,32]有研究表示随着年龄增长,体内烟酰胺腺嘌呤二核苷酸磷酸(NAD+)生成机制会变差及以至人体内NAD+水平变低,导致衰老。研究发发现有特别运输通道(Slc12a8) 能将NMN直接运送到细胞内供体内生成NAD+,以维持NAD+在理想水平,从而缓慢早衰综合征状和正常衰老。[30-32]
NMN(烟酰胺单核苷酸) 对器官的好处
去乙酰酶(Sirtuins)基因涉及衰老与细胞凋亡的过程。研究显示NMN(烟酰胺单核苷酸)激活去乙酰酶基因制造其蛋白刺激细胞的修补工作,特别是对那些不会更新的组织,像是心脏、眼及脑,减缓细胞死亡的过程,随后衰老所致疾病可望一边促进细胞的维修机制,一边得到抑制和恢复。[32,34]
对眼部的好处
卓营方Supra NMN内含丰富NMN(烟酰胺单核苷酸) 、虾青素、叶黄素、胡萝卜素和角黄素的天然类胡萝卜素,是不能被人体自行合成, 所以必须由食物或补充剂中摄取。[1-2] 叶黄素是天然类胡萝卜素,是构成视网膜黄斑点及视网膜其他部分的成份。[11] 光线中的蓝波段是最能损坏眼睛及皮肤的光谱,叶黄素可过滤蓝波段光线,从而减低紫外线照射对眼睛和皮肤的伤害。[11-13]
而NMN能维持免疫系统、眼部组织的健康及良好视力,有研究表明NAD +水平的急促下降会导致眼睛迅速发生神经变性和视力丧失,但科学家发现,补充这种分子可以预防不良反应并改善视力。 [15,33-35] 有研究更表示NMN 把去乙酰酶(Sirtuins)基因激活后会生产去乙酰化酶-细胞保护酶(SIRT1-7)具有抗衰老及缓减细胞凋亡能力,而增加了细胞保护酶SIRT1的水平,令视网膜细胞内的氧化应激减少,减少炎症产生,减少对视网膜的伤害。[35]
卓营方Supra NMN的功效:
强力抗氧化 [1,9,17,28]
增强免疫系统防护 [1,17]
保护人体细胞不受紫外线和自由基的伤害 [1,7,13-17,20,31]
促进身体健康增强体质 [1,17,28]
促进皮肤健康和推迟衰老 [7,17,20-21,28,31]
促进心脏及心血管健康 [1,7,17,23-24,29,32]
促进肝脏健康 [2,7,17,32]
有助提升能量,令人更精神 [24-25,28]
有助肌肉运动后迅速复原,缓解运动后疲劳 [7,26]
有助维持眼睛健康,推迟视力老化 [7,15-18,27,32-35]
Composition 成分:
Beta-nicotinamide mononucleotide, emulsifier (460), gelatin capsules, haematococcus pluvialis, anticaking agent (551,572)
β-烟酰胺单核苷酸、乳化剂(460)、明胶胶囊、雨生红球藻、抗结剂(551、572)
Directions 服法:
Adults take 2 capsules daily with meal or as recommended by your physicians.
成人每天建议餐后服用2粒或遵照医生指示。
Storage 存放方法:
Store below 25 ℃ in a dry and cool place.
Keep out of reach of children.
请存放于摄氏25 ℃以下干爽阴凉处。
勿让儿童自取。
参考文献:
References:
- Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications–A Review. Mar Drugs. 2014;12(1):128-52. doi: 10.3390/md12010128.
2. Kistler A, Liechti H, Pichard L, Wolz E, Oesterhelt G et al. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch Toxicol. 2002;75(11-12):665-75.
3. Lorenz RT, Cysewski GR. Commercial potential for Haematococcous microalgae as a natural source of Astaxanthin. Trends Biotechnol. 2000;18(4):160-7.
4. Kwantes JM, Grundmann O. A brief review of krill oil history, research, and the commercial market. J. Diet Suppl. 2004 Apr 1.
5. Krill – Marine Lipid Complex Technical Data Sheet. NutriScience Innovations: Product Information. Available online at http://www.nutriscienceusa.com/KrillOilMLC.htm
6. Fish oil vs. krill oil. Omega-Research. Available online at http://www.omega-research.com/
7. Yuan JP, Peng J, Yin K, Wang JH. Potential health-promoting effects of Astaxanthin: A high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011;55(1):150-65.
8. Spiller GA, Dewell A. Safety of an Astaxanthin-Rich Haematococcus pluvialis Algal Extract: A Randomized Clinical Trial. J Med Food. 2003 Spring;6(1):51-6.
9. Astaxanthin. Martindale: The Complete Drug Reference. Available online at: http://www.medicinescomplete.com
10. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011;16(4):355-64.
11. Kijlstra A, Tian Y, Kelly ER, Berendschot TT. Lutein: More than just a filter for blue light. Prog Retin Eye Res. 2012;31(4):303-15.
12. Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K. Neuroprotective effects of lutein in the retina. Curr Pharm Des. 2012; 18(1):51-6.
13. Carpenter KL, van der Veen C, Hird R, Dennis IF, Ding T, Mitchinson MJ. The carotenoids beta-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDLoxidation. FEBS Lett. 1997;401(2-3):262-6.
14. Barros MP, Poppe SC, Bondan EF. Neuroprotective properties of the marine carotenoid astaxanthin and omega-3 Fatty acids, and perspectives for the natural combination of both in krill oil. Nutrients. 2014;6(3):1293-317.
15. Lin JB, Kubota S, Ban N, Yoshida M, Santeford A, Sene A, Nakamura R, Zapata N, Kubota M, Tsubota K, Yoshino J, Imai SI, Apte RS. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016 Sep 27;17(1):69-85. doi: 10.1016/j.celrep.2016.08.073. PMID: 27681422; PMCID: PMC5104206.
16. Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K et al. Amelioration of ultraviolet-induced photokeratitis in mice treated with Astaxanthin eye drops. Mol Vis. 2012;18:455-64.
17. Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol. 2003;21(5):210-6.
18. Ohgami K, Shiratori K, Kotake S, Nishida T, Mizuki N et al. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol Vis Sci. 2003;44(6):2694-701.
19. Suzuki Y, Ohgami K, Shiratori K, Jin XH, Ilieva I et al. Suppressive effects of astaxanthin against rat endotoxin induced uveitis by inhibiting the NF-kB signaling pathway. Exp Eye Res. 2006;82(2):275-81.
20. Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R et al. Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage. J Pharm Sci. 2012;101(8):2909-16.
21. Santos SD, Cahú TB, Firmino GO, de Castro CC, Carvalho LB Jr et al. Shrimp waste extract and astaxanthin: Rat alveolar macrophage, oxidative stress and inflammation. J Food Sci. 2012;77(7):H141-6.
22. Fassett RG, Coombes JS. Astaxanthin: A potential therapeutic agent in cardiovascular disease. Mar Drugs. 2011;9(3):447-65.
23. Fassett RG, Coombes JS. Astaxanthin in cardiovascular health and disease. Molecules. 2012;17(2):2030-48.
24. Song XD, Zhang JJ, Wang MR, Liu WB, Gu XB, Lv CJ. Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells. Biol Pharm Bull. 2011;34(6):839-44.
25. Wolf AM, Asoh S, Hiranuma H, Ohsawa I, Iio K et al. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem. 2010;21(5):381-9.
26. Djordjevic B, Baralic I, Kotur-Stevuljevic J, Stefanovic A, Ivanisevic J et al. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young players. J Sports Med Phys Fitness. 2012;52(4):382-92.
27. Cort A, Ozturk N, Akpinar D, Unal M, Yucel G et al. Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure. Regul Toxicol Pharmacol. 2010;58(1):121-30.
28. Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528. doi: 10.1016/j.cmet.2017.11.002. Epub 2017 Dec 14. PMID: 29249689; PMCID: PMC5842119.
29. Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Geroscience. 2019 Oct;41(5):619-630. doi: 10.1007/s11357-019-00074-2. Epub 2019 May 29. PMID: 31144244; PMCID: PMC6885080.
30. Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57. doi: 10.1038/s42255-018-0009-4. Epub 2019 Jan 7. Erratum in: Nat Metab. 2019 Jul;1(7):743. PMID: 31131364; PMCID: PMC6530925.
31. Kincaid JW, Berger NA. NAD metabolism in aging and cancer. Experimental Biology and Medicine. 2020;245(17):1594-1614. doi:10.1177/1535370220929287
32. Kane, A. and D. Sinclair. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research .2018(123): 868–885.
33. Ebeling, Mara & Polanco, Jorge & Qu, Jun & Tu, Chengjian & Montezuma, Sandra & Ferrington, Deborah. (2020). Improving retinal mitochondrial function as a treatment for age-related macular degeneration. Redox Biology. 34. 101552. 10.1016/j.redox.2020.101552.
34. Jadeja RN, Thounaojam MC, Bartoli M, Martin PM. Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration. Oxid Med Cell Longev. 2020 May 9;2020:2692794. doi: 10.1155/2020/2692794. PMID: 32454935; PMCID: PMC7238357.
35. Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020 Dec 29;12. doi: 10.18632/aging.202453. Epub ahead of print. PMID: 33373320.
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