YesNutri Joint Care Gold Tablets 

YesNutri Joint Care Gold Tablet is an outstanding product combining high quality Collagen,Pharma Grade Chondroitin, with MSM and Herbs. This product is manufactured by a well-known USA cGMP manufacturer.

An all-rounded Supplement
Joint Care Gold Tablets (11 in 1 Formula) is a high graded product made from 11 kinds of high quality Collagen, Glucosamine, Chondroitin, with MSM and Herbal Extracts. It assists bone remodeling, helps relieve joint pain and swelling, enhance joint mobility and lubricate joints. Besides, this product contain vitamin C can enhance collagen production for repairing bones and worn-out joints and soft tissues. Vitamin D3 can enhance the absorption of minerals such as calcium and phosphorus, enhance bone strength and reduce bone loss. Vitamin C and D3 both enhance the immune system.

Composition 

Glucosamine hydrochloride, chondroitin sulfate, collagen hydrolysate, emulsifier (460,462), MSM (methyl sulfonyl methane), boswellia serrata extract, turmeric extract, anticaking agent (551,570,572), ascorbic acid, sodium borate , stabilizer (468), glazing agent (904), manganese sulfate, cholecalciferol, nattokinase

Directions 

Adult: Take 1 tablet 2 times daily.

Storage 

Store below 25℃ in a dry and cool place.

Keep out of reach of children.

Joint Care Gold Tablet 

Importance of Collagen Supplementation

Starting from the age of 25, our collagen level reduces at a rate of 1.5% every year as part of the aging process. Collagen reduction will increase the risk of suffering joints pain and elongate the recovery time from injury. And by the age of 45, collagen level in our body will reduce by up to 30%.[1-2]

Attributes of the Joint Nourishing Ingredients

Collagen is the main structural protein found in our body. It accounts for about 30% of all protein in our body and is essential for the growth and development of muscles, tendons and bones. Collagen also provides the strength and elasticity that our body tissues need.[3-5] Studies have shown that collagen hydrolysate can effectively replace the collagen that is lost through normal aging process.[7-8] Not only is this beneficial to our muscles and joints, it can also help to keep our skin, hair and nails healthy.[7-8]

Chondroitin Sulphate comes from natural resource, such as shark or bovine cartilage.[9-11] It is a major component of cartilage – the tough, connective tissue that cushions the joints.[9-11] Chondroitin helps to keep cartilage healthy by absorbing fluid (particularly water) into the connective tissue.[9-11] It may also block enzymes that break down cartilage, and provide the building blocks for the body to produce new cartilage.[9-11]

Glucosamine plays an important role in making glycosaminoglycans and glycoproteins, which are essential building blocks of many parts of your joints, including ligaments, tendons, cartilage and synovial fluid. [20]

MSM (Methylsulfonylmethane) is an important source of organic sulfur, which is required for development and maintenance of connective tissues. [13-15]MSM can strengthen and increase flexibility of the muscles, bones and joints. MSM is also the vital component in the formation of keratin, collagen and elastin, which smooths the skin, strengthens hair and nails and enhance growth of hair and nails. [13-17]

Manganese and Boron are essential trace mineral elements for the body, especially for bones and muscles. Manganese helps increase bone density and prevents bone loss. [22] Boron focuses on bone health and muscle. It aid for building muscles and for improving muscle coordination to support joint activities.[23,24]

Attributes of the Relieving Joint Discomfort Ingredients

Boswellia is an Indian herb. Its natural extract comes from the gums and resins of Boswellia serrata. [12-13] Boswellia helps to remove toxin from the joints, support and increase the mobility of the joints, suppress underlying pain, reduce joint swells and stiffness. [12-13]

Turmeric can extract a yellow coloring agent named curcumin. It shows strong anti-oxidative and anti-inflammatory activities. [27] It can play a key role in the prevention of chronic inflammation diseases as it able to reduce the oxidative stress of the body; Curcumin can relieve the pain caused by chronic arthritis. [28]

Nattokinase is an enzyme that is extracted from a popular Japanese food called natto, which is boiled soybeans that have been fermented with a bacterium called Bacillus subtilis natto. [25] Nattokinase has the ability of dissolving fibrin and acts as an anticoagulant. It may reduce blood clot and enhance blood flow to supply the nutrients for bone, joint and cartilage tissue repairing or reconstruction. [26, 28]

Advance Technology in Hydrolyzed Collagen Production

By means of advance technology, the fine product resulting from bone and cartilage that has been broken down into small components that can collectively be referred to as hydrolyzed collagen. Hydrolyzed collagen can easily be absorbed throughout the body and rejuvenate our bones, joints and cartilage.

An all-rounded Supplement

Collagen Hydrolysate (Enriched with Glucosamine, Chondroitin, MSM and Herbal Extracts) is a high graded product made from 11 kinds of high quality Collagen, Glucosamine, Chondroitin, with MSM and Herbal Extracts. It assists bone remodeling, helps relieve joint pain and swelling, enhance joint mobility and lubricate joints. Besides, this product contain vitamin C can enhance collagen production for repairing bones and worn-out joints and soft tissues. Vitamin D3 can enhance the absorption of minerals such as calcium and phosphorus, enhance bone strength and reduce bone loss. Vitamin C and D3 both enhance the immune system.

Beneficial effects of Collagen Hydrolysate Plus MSM include:

• reduce risk of joint pain and swelling[7,10-17,21,23,24,28]
• promote cartilage formation in joints[7,10-17]
• maintain healthy cartilage and supplement synovial fluid[7,10-17]
• help regulate skin tone, firmness and reduce cellulite [6,18]
• anti-oxidizing effect[21,24]
• reduce fine lines, wrinkles, stretch marks and scars[19]
• smooths the skin, strengthen hair and nails[13-15]Z

Recommended daily dose: 

Adults take 1 tablet twice daily, or as directed by physicians.

References:

1. Hall DA. The pathophysiology of ageing collagen. Proc R Soc Med. 1976;69(12): 923-4.
2. Moriguchi T, Fujimoto D. Age-related changes in the content of the collagen crosslink, pyridinoline. J Biochem. 1978;84(4):933-5.
3. Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002;277(6):4223-31.
4. Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J. Collagen: The Fibrous Proteins of the Matrix. Molecular Cell Biology (4th ed). New York: W. H. Freeman; 2000.
5. Bailey AJ, Paul RG, Knott L. Mechanisms of maturation and ageing of collagen. Mech Ageing Dev. 1998;106(1-2):1-56.
6. Baumann L. Skin ageing and its treatment. J Pathol. 2007;211(2):241-51.
7. Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food. 2011;14(6):618-24.
8. Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y. The protective effects of long-term oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague-Dawley male rats. J Food Sci. 2010;75(8):H230-8.
9. Chai HJ, Li JH, Huang HN, Li TL, Chan YL, Shiau CY, Wu CJ. Effects of sizes and conformations of fish-scale collagen peptides on facial skin qualities and transdermal penetration efficiency. J Biomed Biotechnol. 2010 June 8, doi: 10.1155/2010/757301.
10. MONOGRAPHS Chondroitin Sulfates. Altern Med Rev. 2006;10(4):338-43.
11. Gregory PJ, Sperry M, Wilson AF. Dietary supplements for osteoarthritis. Am Fam Physician. 2008; 77(2): 177-84.
12. Gupta PK, Samarakoon SM, Chandola HM, Ravishankar B. Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis). Ayu. 2011;32(4):478-82.
13. We SR, Jeong EO, Koog YH, Min BI. Effects of nutraceuticals on knee osteoarthritis: Systematic review. Afr J Biotechnol. 2012;11(12):2814-21.
14. MONOGRAPHS Methylsulfonylmethane (MSM). Altern Med Rev. 2003;8(4):438-41.
15. Roth RA, Townsend CE. Sulfur (MSM) – A Basic Essential Nutrient Needed Now, More than Ever Before. Nutrition & Diet Therapy (8th ed). New York: Academic Press; 2003.
16. Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R et al.Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50.
17. Magrans-Courtney T, Wilborn C, Rasmussen C, Ferreira M, Greenwood L et al. Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program. J Int Soc Sports Nutr. 2011;8:8.
18. Rawlings AV. Cellulite and its treatment. Int J Cosmet Sci. 2006;28(3):175-90.
19. Bauza E, Oberto G, Berghi A, Dal CF, Domloge N. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. Int J Tissue React. 2004;26(3-4):105-11.
20. Thoria Donia, Ehab M.M. Ali, Abdel-Halim Abdel-Hady Mostafa. Biochemical Effects of glucosamine on glycoproteins of rats with hepatic fibrosis. Int. J. of Adv. Res. 2016;4(3): 1845-1859] (ISSN 2320-5407).
21. He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules. 2015 May 20;20(5):9183-213. doi: 10.3390/molecules20059183. PMID: 26007179; PMCID: PMC6272784.
22. Keen CL, Zidenberg-Cherr S. Manganese. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington D.C.: ILSI Press; 1996:334-343.
23. Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994 Nov; 102 Suppl 7(Suppl 7):83-5. doi: 10.1289/ehp.94102s783. PMID: 7889887; PMCID: PMC1566627.
24. Nielsen FH. Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect. 1994;102(suppl 7):59–63.
25. Yanagisawa Y, Chatake T, Chiba-Kamoshida K, Naito S, Ohsugi T, Sumi H, et al. (December 2010). “Purification, crystallization and preliminary X-ray diffraction experiment of nattokinase from Bacillus subtilis natto”. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66 (Pt 12): 1670–3. doi:10.1107/S1744309110043137. PMC 2998380. PMID 21139221
26. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. Published 2015 Jun 25. doi:10.1038/srep11601
27. National Center for Biotechnology Information. PubChem Compound Summary for CID 969516, Curcumin. https://pubchem.ncbi.nlm.nih.gov/compound/Curcumin. Accessed Dec. 11, 2020.
28. Chaiyasit, Kamon, and Viroj Wiwanitkit. “Natto supplementation and decreased platelet count in a case with rheumatoid arthritis.” Annals of Tropical Medicine and Public Health, vol. 6, no. 3, 2013, p. 387. Accessed 11 Dec. 2020.